PD33-08 SINGLE-CELL TRANSCRIPTOME ANALYSIS OF HUMAN SPERMATOGONIAL STEM CELLS
نویسندگان
چکیده
منابع مشابه
mouse and human spermatogonial stem cells
spermatogonial stem cells (sscs) are in the beginning of a complex process in which they transmit genetic information from generation to generation. any failure in this process can result in infertility. it has been suggested that transplantation of spermatogonial stem cells, following their maintenance and culturing, may restore fertility in some infertile patients. because fertility restorati...
متن کاملI-13: Transcriptome Dynamics of Human and Mouse Preimplantation Embryos Revealed by Single Cell RNA-Sequencing
Background: Mammalian preimplantation development is a complex process involving dramatic changes in the transcriptional architecture. However, it is still unclear about the crucial transcriptional network and key hub genes that regulate the proceeding of preimplantation embryos. Materials and Methods: Through single-cell RNAsequencing (RNA-seq) of both human and mouse preimplantation embryos, ...
متن کاملMouse and Human Spermatogonial Stem Cells
Spermatogonial stem cells (SSCs) are in the beginning of a complex process in which they transmit genetic information from generation to generation. Any failure in this process can result in infertility. It has been suggested that transplantation of spermatogonial stem cells, following their maintenance and culturing, may restore fertility in some infertile patients. Because fertility restorati...
متن کاملO-3: Identification and Characterization of Repopulating Spermatogonial Stem Cells from The Adult Human Testis
Background: This study was conducted to identify and characterize repopulating spermatogonial stem cells (SSCs) in the adult human testes. Materials and Methods: Testes biopsies from obstructive azoospermic patients and normal segments of human testicular tissue were used. Flow cytometry, real time PCR and immunohistochemical analysis were performed. Purified human spermatogonia were transplant...
متن کاملPlasticity of spermatogonial stem cells
There have been significant breakthroughs over the past decade in the development and use of pluripotent stem cells as a potential source of cells for applications in regenerative medicine. It is likely that this methodology will begin to play an important role in human clinical medicine in the years to come. This review describes the plasticity of one type of pluripotent cell, spermatogonial s...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2018
ISSN: 0022-5347,1527-3792
DOI: 10.1016/j.juro.2018.02.1563